TDO2 (tryptophan 2,3-dioxygenase), also known as TO (tryptophan oxygenase) or TRPO (tryptophan pyrrolase), is a 406aa protein that belongs to the tryptophan 2,3-dioxygenase family.
Existing as a homotetramer, TDO2 binds two heme groups per tetramer.
TDO2 has broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin, and it incorporates oxygen into the indole moiety of tryptophan.
In doing so, TDO2 plays a major role in the tryptophan metabolism pathway.
The gene that encodes TDO2 consists of approximately 65,669 bases and maps to human chromosome 4q32.1.
Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes.
Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington’s disease, is on located on chromosome 4.
Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia, polycystic kidney disease, thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human TDO2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Recombinant protein corresponding to human TDO2.
