84-4401-39　［取扱停止］TAL1, acetylated (K221/K222) (T-Cell Acute Lymphocytic Leukemia Protein 1, TAL-1, Class A Basic Helix-loop-helix Protein 17, bHLHa17, Stem Cell Protein, T-Cell Leukemia/Lymphoma Protein 5, T-Cell acute Lymphocytic Leukemia Protein 2, TAL-2, Class A Basic Helix-loop-helix Protein) 100ul　361277

特徴

• Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder.
• TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helix transcription factor known to regulate embryonic hematopoiesis.
• This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box.
• In addition, leukemogenesisis accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of case in kinase IIalpha, a serine/threonine protein kinase known to modulate the activity of other betaHLH transcription factors.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.