Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles.
The Synaptotagmin family of proteins share a common domain structure that consists of a transmembrane domain and a cytoplasmic region composed of two C2 domains.
Synaptotagmin VIII, also known as SYT8, is a 401aa single-pass type III membrane protein belonging to the Synaptotagmin family.
Containing two C2 domains, Synaptotagmin VIII exists as a homodimer or homooligomer.
Synaptotagmin VIII exists as two alternatively spliced isoforms, isoform 1 and isoform 4.
Synaptotagmin VIII isoform 4 is thought to participate in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human SYT8. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human SYT8.
