84-4400-76　［取扱停止］SRI (Sorcin, 22kD Protein, CP-22, CP22, V19) 100ul　361239

特徴

• Sorcin is a highly conserved protein, with 95% homology between hamster and human sorcin sequences.
• Sorcin has four putative Ca-binding domains, two of which exhibit strong homology to calmodulin “EF hand” motifs.
• Calcium binding directly to sorcin has been demonstrated by in vitro assays.
• Sorcin is closely related to members of calpain and sarcoplasmic Ca2+-binding protein subfamilies.
• Sorcin undergoes calcium-dependent translocation from the cytosol to cellular membranes.
• Sorcin binds to and modulates ryanodine receptors and is widely distributed including heart and brain tissues.
• At the subcellular level, sorcin localizes to T-tubule junctions of cardiac sarcoplasmic reticulum.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.