84-4400-65　［取扱停止］SQSTM1 (Sequestosome-1, EBI3-associated Protein of 60kD, EBIAP, p60, Phosphotyrosine- independent Ligand for the Lck SH2 Domain of 62kD, Ubiquitin-binding Protein p62, SQSTM1, ORCA, OSIL) 50ul　361234

特徴

• The chronic focal skeletal disorder, Paget’s disease of bone, affects 2-3% of the population over the age of 60 years.
• Paget’s disease is characterized by increased bone resorption by osteoclasts, followed by abundant new bone formation that is of poor quality.
• The disease leads to several complications including bone pain and deformities, as well as fissures and fractures.
• Mutations in the ubiquitin-associated (UBA) domain of the Sequestosome 1 protein (SQSTM1), also designated p62 or ZIP, commonly cause Paget’s disease since the UBA is necessary for aggregate sequestration and cell survival.
• The SQSTM1-L1 gene product, also known as LOC647259, has been provisionally designated SQSTM1-L1 pending further characterization.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.