BGT-1, also known as sodium- and chloride-dependent betaine transporter, SLC6A12 (solute carrier family 6 member 12) or Na(+)/Cl(-) betaine/GABA transporter, is a 614aa protein.
As a multi-pass membrane protein, BGT-1 localizes to liver, heart, skeletal muscle and placenta and is widely distributed in brain.
BGT-1 has the typical structure of neurotransmitter transporters, with twelve transmembrane domains and a large extracellular loop between the third and fourth transmembrane domains.
BGT-1 transports betaine and GABA, and may have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
BGT-1 is associated with mucus production in asthma, and could affect reversibility of lung function abnormalities in aspirin-intolerant asthma patients.
BGT-1 displays significant functional differences from the other members of the GABA transporter family.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM Sodium azide.
Specificity：Recognizes human SLC6A12. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human SLC6A12.
