SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454aa docking protein that belongs to the SH2 signaling protein family.
Members of this family typically participate in intracellular signaling.
Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain.
SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins.
This suggests that SH2D4A, via its SH2 domain, may play an important function in cellular signal transduction.
More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction.
In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human SH2D4A. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human SH2D4A.
