84-4399-33　［取扱停止］SEPX1 (Methionine-R-sulfoxide Reductase B1, MsrB1, Selenoprotein X, SelX, MSRB1, HSPC270) 100ul　361159

特徴

• Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of selenoproteins.
• Nutritional deficiency of selenium decreases selenoprotein concentrations and leads to pathologic conditions.
• Most of the known selenoproteins are members of the glutathione peroxidase or iodothyronine deiodinase families.
• Selenoprotein P (SEPP1) is a major selenoprotein that is not a member of those families.
• It is an extracellular glycoprotein that is present in several isoforms and is the only selenoprotein known to contain multiple selenocysteine residues.
• SECIS elements form stem-loop structures in the 3' untranslated regions (UTR) of eukaryotic mRNAs that encode selenoproteins.
• The Selenoprotein W SECIS elements contain an additional highly conserved base-paired stem that may prevent inappropriate selenocysteine incorporation at the UGA stop codons.
• Selenoprotein R, also designated methionine-R-sulfoxide reductase or Selenoprotein X1, is a zinc binding protein.
• The gene encoding for Selenoprotein R contains seleno-cysteine, which is encoded by the usual stop codon TGA at the active site.
• Selenoprotein R may play a role in protection against oxidative stress.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.