The SCO1 and SCO2 protein homologs belong to the SCO1/2 family of proteins.
SCO1 and SCO2 both localize to the mitochondrion and are inner membrane proteins crucial for copper insertion or transport to the active site of cytochrome c oxidase (COX).
COX is a crucial component in energy production because it functions as the terminal enzyme in the respiratory chain.
SCO1 is predominantly expressed in highly oxidative phosphorylation tissues such as brain, heart and muscle, while SCO2 is ubiquitously expressed.
Defects in the gene encoding for SCO1 may cause cytochrome c oxidase deficiency, a hetero-genous disorder.
Defects in the gene encoding for SCO2 may cause cardioencephalomyopathy with cytochrome c oxidase deficiency, a fatal infantile disorder characterized by hypertrophic cardiomyopathy, lactic acidosis and gliosis.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human SCO1.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human SCO1.
