84-4399-08　［取扱停止］SCN-pan (Sodium Channel Protein type 1 Subunit alpha, Sodium Channel Protein brain I Subunit alpha, Sodium Channel Protein type I Subunit alpha, Voltage-gated sodium Channel Subunit alpha Nav1.1, SCN1A, NAC1, SCN1) 50ul　361143

特徴

• Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells.
• During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell.
• The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit.
• The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction.
• The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons.
• The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle.
• In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei.
• Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.