84-4398-21　［取扱停止］RNF7 (RING-Box Protein 2, Rbx2, CKII beta-Binding Protein 1, CKBBP1, RING Finger Protein 7, Regulator of cullins 2, Sensitive to Apoptosis Gene Protein, RBX2, ROC2, SAG) 50ul　361099

特徴

• The protein encoded by this gene is a highly conserved ring finger protein.
• It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction.
• This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII).
• The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of Ikappa Balpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B).
• Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution: Immunofluorescence: 1:50-1:200Western Blot: 1:500-:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.