RDM1 (RAD52 motif-containing protein 1) is a 284aa protein that is expressed in testis.
RDM1 is involved in the cellular response to cisplatin, a drug commonly used in chemotherapy.
Human RDM1 shares 71.1% and 51.2%aa identity with mouse and chicken RDM1, respectively.
RDM1 exists as 11 alternatively spliced isoforms and only exon 3 is common to all varants.
Usage of two translational start sites, one in exon 1 and the other in intron 1, produces RDM1 isoforms with either long or short N-terminal, and RDM1 isoforms have great diversity in their C-terminal as well.
The RDM1 protein contains two motifs: a motif found in Rad52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in Rad52.
The RDM1 gene contains seven coding exons, is conserved in chimpanzee, canine, bovine, mouse, rat, chicken and zebrafish, and maps to human chromosome 17q12.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human RDM1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human RDM1.
