84-4397-74　［取扱停止］RASSF5 (Ras association Domain-Containing Protein 5, New ras effector 1, Regulator for Cell Adhesion and polarization enriched in lymphoid tissues, RAPL, NORE1, RAPL) 50ul　361073

特徴

• Potential tumor suppressor.
• Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation.
• Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1.
• Together with RAP1A may participate in regulation of microtubule growth.
• The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing.
• May be involved in regulation of Ras apoptotic function.
• The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.