Ras is a small GTP-binding protein involved in many cellular processes, including proliferation, differentiation and apoptosis.
Ras transmits signals of cell surface receptors by binding to a variety of effector molecules.
In addition to the well characterized effectors Raf and PI 3-kinase, Ras also interacts with members of the RASSF family, including RASSF1, RASSF2, RASSF3, RASSF4 and Nore1.
Members of the RASSF family contain a highly conserved Ras association domain (Ral GDS/AF-6 or RA) and function as Ras effectors/tumor suppressors.
RASSF3 (Ras association domain family 3) is a ubiquitously expressed protein found in normal and cancerous tissues.
RASSF3 contains an N-terminal RA domain and a coiled-coil SARAH domain.
Three isoforms, namely RASSF3A, RASSF3B and RASSF3C, may exist for RASSF3 due to alternative splicing.
RASSF3B and RASSF3C are shorter than RASSF3A and do not contain the RA and SARAH domain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human RASSF3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human RASSF3.
