84-4397-64　［取扱停止］RARRES2 (Retinoic Acid Receptor Responder Protein 2, Chemerin, RAR-responsive Protein TIG2, Tazarotene-induced Gene 2 Protein, TIG2) 50ul　361068

特徴

• Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs).
• Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted.
• TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles and endothelial cells as well as in pancreas, spleen and intestine.
• TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids.
• TIG1 is a single-pass type II membrane protein activated by tazarotene and RAR proteins.
• It belongs to the protease inhibitor I47 (latexin) family of proteins.
• TIG2 is a secreted protein that is mainly expressed in epidermis, hair follicles and endothelial cells.
• TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.
• TIG3 is widely expressed in most tissues, but is not detected in heart, testis or brain.
• TIG3, which is activated by tazarotene, belongs to the H-rev107 family of proteins.
• TIG3 acts as a growth regulator and is important for mediating the growth suppressive effects of retinoids.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.