84-4397-18　［取扱停止］PXMP2 (Peroxisomal Membrane Protein 2, 22kD Peroxisomal Membrane Protein, PMP22) 50ul　361043

特徴

• Peroxisomes are subcellular organelles with important functions in lipid metabolism that are found in virtually all eucaryotic cells.
• The peroxisomal membrane contains a number of integral and peripheral membrane proteins involved in the import of peroxisomal matrix proteins and the transport of metabolites across the membrane.
• Pxmp2 (Peroxisomal membrane protein 2), also known as PMP22, is a 195aa multi-pass membrane protein that belongs to the peroxisomal membrane protein PXMP2/4 family.
• The Pxmp2 protein interacts with both Peroxin 19 and Siva proteins.
• The Peroxin 19 protein binds multiple peroxisomal membrane proteins (PMPs), is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.
• Pxmp2 is the most abundant peroxisomal membrane protein in higher eukaryotes.
• Pxmp2’s expression is tissue-specific with highest levels of expression in liver, kidney and heart tissue.
• It has been suggested that Pxmp2 is involved in pore-forming activity and may contribute to the broad permeability of the peroxisomal membrane.
• Disruption of the mouse Pxmp2 gene leads to partial restriction of peroxisomal membrane permeability to solutes in vitro and in vivo.
• The Pxmp2 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly and mosquito, and maps to human chromosome 12q24.33.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.