84-4397-16　［取扱停止］PVALB (Parvalbumin alpha) 50ul　361042

特徴

• The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 alpha and beta, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin alpha and parvalbumin B, also designated oncomodulin (OCM).
• Structurally and evolutionarily conserved, parvalbumin alpha and OCM proteins are distinct in expression and function.
• Parvalbumin alpha, also designated parvalbumin (PV), is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues, including kidney and parathyroid.
• Research indicates that parvalbumin alpha plays a significant role in muscle relaxation.
• OCM was originally thought to have expression restricted to neoplastic tissues, early embryonic cells and certain tumor cell lines.
• Recent research shows that OCM is also expressed and secreted by macrophages where, in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration.
• OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals.
• In humans, two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951).
• These genes encode proteins 109aa in length which share 99% sequence identity.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.