84-4397-05　PTMA (Prothymosin alpha, Cleaved into the Following 2 Chains, Prothymosin alpha, N-terminal Processed, Thymosin alpha-1, TMSA) 100ul　361036

特徴

• Prothymosina (PTa) is a nuclear protein that is widely expressed in mammalian tissues, including kidney, liver, spleen, normal lymphocytes, human T cell leukemia virus-infected T cells and myeloma cells.
• The human PTa gene maps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution, which correlates to transcription sites.
• PTa is a chromatin-remodeling protein that was initially thought to mediate T lymphocyte maturation, but subsequently has been shown to be involved in cell cycle progression, proliferation and cell differentiation.
• PTa is thought to be transported into the nucleus by the karyopherin B1-Rch-1 complex, where it associates with Histones H2A, H2B, H3 and H4.
• Also, PTa is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin a-phosphorylating kinase (PTaK) in amitogen activating pathway.
• The N-terminal of PTa is cleaved to produce a secreted, biologically active peptide thymosin a1,which may be used as an immunomodulator in cancer patients and patients with chronic active hepatitis, or as an immuno enhancer of vaccines in immuno compromised individuals.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.