84-4396-77　［取扱停止］PRPF40A (Pre-mRNA-processing Factor 40 Homolog A, Fas Ligand-Associated Factor 1, Formin-binding Protein 11, Formin-binding Protein 3, Huntingtin yeast partner A, Huntingtin-Interacting Protein 10, HIP-10, Huntingtin-Interacting Protein A, Renal Carcinoma Antigen) 50ul　361023

特徴

• FNBP3, Formin-binding protein 3, is a 957aa protein encoded by the human gene PRPF40A.
• FNBP3 belongs to the PRPF40 family and contains five FF domains and two WW domains.
• Nuclear proteins harboring both WW and FF protein interaction modules bind to splicing factors as well as RNA polymerase II and may serve to link transcription with splicing.
• Through the WW domains, FNBP3 will bind to the Formin proline-rich regions.
• Also known as Pre-mRNA- processing factor 40 homolog A, FNBP3 binds to WASL/N-WASP (Neuronal Wiskott-Aldrich syndrome protein) complex and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function.
• FNBP3 is widely expressed in most tissues and is localized to the nuclear speckles.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.