84-4396-67　［取扱停止］PRL (Prolactin) 50ul　361018

特徴

• Protein tyrosine phosphatases (PTPs) play a role in regulating diverse cellular processes.
• They form a small class of prenylated protein phosphatases called PRL proteins characterized by a C-terminal consensus sequence for prenylation.
• PRL-1, also designated Protein tyrosine phosphatase type IVA protein 1 (PTP4A1), is a unique nuclear PTP that is induced in regenerating liver and mitogen-stimulated cells.
• It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines.
• PRL-2 (Protein tyrosine phosphatase type IVA protein 2, or PTP4A2) is ubiquitously expressed with highest levels in heart, skeletal muscle and thymus but is also overexpressed in prostate tumor tissue.
• PPRL-2 is stimulates progression from G1 into S phase during mitosis and promotes tumors.
• PRL-3, also known as Protein Tyrosine Phosphatase Type IVA, member 3 (PTP4A3) is expressed in heart and skeletal muscle as well as epithelial cells of the small intestine and associates with the cell plasma membrane.
• Over expression of PRL-3 inhibits angiotensin-II induced cell calcium mobilization and promotes cell growth.
• PRL-3 is important for colorectal cancer metastasis and may serve as a new therapeutic target for this condition.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.