The PR-domain containing proteins (PRDMs) have a common involvement in the modulation of gene activities.
A PR-domain family member usually produces two products, which differ by the presence or absence of the PR domain.
The PR-plus product is underexpressed or disrupted, whereas the PR-minus product is present or overexpressed in cancer cells.
This imbalance in the amount of the two products, which is a result of either genetic or epigenetic events, appears to be a determining cause of malignancy.
PRDM10 (PR domain containing 10), also known as PFM7 or TRIS, is a 1,147 amino acid protein that contains ten C2H2-type zinc fingers and one SET domain.
Existing as six alternatively spliced isoforms, PRDM10 localizes nucleus and may be involved in transcriptional regulation.
PRDM10 may also play a role in the development of the central nerve system, as well as in the pathogenesis of neuronal storage disease.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human PRDM10. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human PRDM10.
