PINX1 (PIN2/TRF1-interacting protein X1), also known as LPTL or LPTS (liver-related putative tumor suppressor), is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles.
PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus.
PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT.
The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity.
Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity.
The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells.
This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation.
In addition, PINX1 is involved in nucleolar RNA maturation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human PINX1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human PINX1.
