84-4395-71　［取扱停止］PIK3CG (Phosphatidylinositol 4,5-bisphosphate 3-Kinase Catalytic Subunit gamma isoform, PI3-Kinase Subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-Kinase Subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-Kinase 110kD Catalytic Subunit gamma, PtdIns-3-kinase) 100ul　360968

特徴

• Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits.
• p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase.
• Two forms of p85 have been described (p85a and p85B), each possessing one SH3 and two SH2 domains.
• Various p110 isoforms have been identified.
• p110a and p110B interact with p85a, and p110a has also been shown to interact with p85B in vitro.
• p110d expression is restricted to white blood cells.
• It has been shown to bind p85a and p85B, but it apparently does not phosphorylate these subunits.
• p110d seems to have the capacity to autophosphorylate.
• p110g does not interact with the p85 subunits.
• It has been shown to be activated by a and BG heterotrimeric G proteins.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.