Poly(ADP-ribose) polymerase-3 (PARP-3) is part of the base excision repair (BER) pathway, catalyzing the poly(ADP-ribosyl)ation of nuclear proteins.
Poly(ADP-ribosyl)ation, a post-translational modification following DNA damage, appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
PARP-3 is a nuclear, DNA-binding protein, which interacts with PARP-1.
PARP-3 is present in actively dividing tissues with highest levels in the kidney, skeletal muscle, liver, heart and spleen.
Human PARP-3 maps to chromosome 3p21-3-p21.1, a gene region that undergoes alteration in solid malignant tumors.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human PARP3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human PARP3.
![PARP3 (Poly [ADP-ribose] Polymerase 3 (EC:2.4.2.30), PARP-3, hPARP-3, ADP-ribosyltransferase Diphtheria Toxin-like 3, ARTD3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] Synthase 3, pADPRT-3, ADPRT3, ADPRTL3) 50ul](https://aimg.as-1.co.jp/c/84/4395/08/85133520.jpg)