Oncostatin M (OSM) is a glycoprotein that inhibits the growth of a broad range of human tumor cell lines, but does not influence the growth of normal human fibroblasts.
Expression of OSM is greatest in activated monocytic and lymphocytic cell lines and in normal adherent macrophages.
Aa sequence analysis of OSM has revealed homology with leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF) and interleukin 6 (IL-6), all of which affect the growth and differentiation of a broad range of cell types, including those of hematopoietic origin.
OSMR beta(oncostatin M receptore beta), also known as OSMR, is a 979aa single-pass type I membrane protein that functions as a receptor for OSM.
Expressed at high levels in neural cells, as well as fibroblast and epithelial tumor lines, OSMR beta exists as a heterodimer that interacts with interleukins and is able to transduce OSM-induced signaling events.
Defects in the gene encoding OSMR Beta are the cause of primary cutaneous amyloidosis (PCA), an autosomal dominant disorder characterized by chronic itching of the skin.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human OSMR. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Recombinant protein corresponding to human OSMR.
