Alpha 1 acid glycoprotein (AGP) is an acute phase plasma protein synthesized by the liver.
It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation.
Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides.
AGP has a high affinity, low capacity binding for basic drugs at physiological pH.
In human plasma, AGP is found at levels of 0.5-1.4mg/ml.
These levels are elevated during acute inflammation; therefore AGP protein levels can be used to diagnose inflammatory conditions.
Multiple AGP genes exist, including AGP 1, AGP 2, AGP 3 and AGP 8.
AGP 1 and AGP 2 contain five and six potential N-glycosylation sites, respectively.
Abnormal expression of the APG 1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG 2 gene are associated with different types of carcinomas.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human ORM1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human ORM1.
