84-4394-48　［取扱停止］NSUN6 (Putative Methyltransferase NSUN6, NOL1/NOP2/Sun and PUA Domain-Containing Protein 1, NOL1/NOP2/Sun Domain Family Member 6, NOPD1) 100ul　360902

特徴

• The nucleolus consists of a number of specific proteins that play a critical role in the assembly of ribosomes, as well as in the maintenance and structural integrity of the nucleolus.
• NSUN6 (NOL1/NOP2/Sun domain family member 6), also known as NOPD1 (NOL1/NOP2/Sun and PUA domain-containing protein 1), is a 469aa protein that belongs to the methyltransferase superfamily.
• NSUN6 contains 1 PUA domain and may have S-adenosyl-L-methionine- dependent methyl-transferase activity.
• The gene encoding NSUN6 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
• Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie-tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.