84-4394-32　［取扱停止］NPAS4 (Neuronal PAS Domain-containing Protein 4, Neuronal PAS4, Class E Basic Helix-loop-helix Protein 79, bHLHe79, HLH-PAS Transcription Factor NXF, PAS Domain-containing Protein 10, NPAS4, BHLHE79, NXF, PASD10) 100ul　360894

特徴

• The Per-Arnt-Sim (PAS) domain is a 270aa motif that mediates associations among various PAS family transcription factors.
• The PAS family contains neuronal specific transcription factors known as NPAS1, NPAS2, NPAS3 and NPAS4, which are involved in the development and maintenance of learning and memory pathways.
• NPAS1 regulates erythropoietin expression in developing brain.
• NPAS2, also designated PAS 4/MOP4, associates with MOP3 to activate transcription.
• NPAS3, which localizes to the nucleus and is ubiquitously expressed in the adult brain, may be involved in neurogenesis and has been implied to control regulatory pathways relevant to psychotic illness and schizophrenia.
• NPAS4 (neuronal PAS domain protein 4), also known as NXF, Le-PAS, PASD10 or bHLHe79, is a 802aa nuclear protein that is exclusively expressed in the brain.
• NPAS4 acts as a transcriptional activator in the presence of Arnt 1, and activates the CME (CNS midline enhancer) element and expression of the Drebrin gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.