Pyrin-containing Apaf1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signal transduction proteins that function in apoptotic and inflammatory signaling pathways.
PYPAF7, also known as Monarch-1, regulates activation of caspase-1 via ASC protein and promotes activation of NF-kappa-B via IKK.
PYPAF7 enhances nonclassical and classical MHC class I expression at the level of the promoter, RNA, and protein expression.
PYPAF7 is present in the cytoplasm of peripheral blood leukocytes, predominantly eosinophils and granulocytes, with lower levels in monocytes.
The PYPAF7 gene maps to human chromosome 19q13.4.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human NLRP12.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human NLRP12.
