NKp46 (lymphocyte antigen 94, LY94) is a natural cytotoxicity receptor that belongs to the immunoglobulin superfamily and is expressed by all resting or activated NK cells, but not on T cells or B cells.
The NKp46 cDNA encodes a 304aa type I transmembrane protein with an extracellular region preceded by a 21 residue signal peptide and two cysteine-bridged C2-type Ig-like domains.
A stem connects the extracellular domain to a 19aa, arginine containing-transmembrane domain.
NKp46 is involved in natural cytotoxicity and is involved in the recognition and lysis of both human and murine tumor cells.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human NKp46.
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human NKp46.
