Actin is a highly conserved protein that is expressed in all eukaryotic cells.
Actin filaments can form both stable and labile structures, and are crucial components of microvilli and the contractile apparatus of muscle cells.
Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interact with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction.
MYH3 (Myosin heavy chain 3), also known as muscle embryonic Myosin heavy chain or SMHCE, is a 1940aa that localizes to the thick filaments of myofibrils.
While highly expressed in fetal skeletal muscle, MYH3 is barely detectable in adult skeletal muscle.
Defects in the gene encoding MYH3, which maps to human chromosome 17p13.1, are the cause of distal arthrogryposis type 2B (DA2B).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05%% sodium azide.
Specificity：Recognizes human MYH8.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to residues in human MYH8.
