Melatonin (Mel), a hormone secreted by the pineal gland, is expressed at night in response to the circadian clock.
Melatonin is thought to be involved in regulating reproductive physiological development and the progression of sexual maturation, and it is also thought to play a role in tumorigenesis.
The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors.
Signaling through the melatonin receptors inhibits adenylate cyclase and stimulates phospholipase Cb upon activation of pertussis toxin (PTX)-sensitive G proteins.
MEL-1A-R may be involved in pacing the biological clock.
However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human MTNR1A. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human MTNR1A.
