Epilysin, also known as matrix metalloproteinase-28 (MMP-28), is a secreted protein that belongs to the peptidase M10A family.
Matrix metalloproteinase proteins are responsible for the breakdown of the extracellular matrix which is important for normal physiological processes such as tissue remodeling, reproduction and embryonic development.
Epilysin is produced by proliferating keratinocytes and is responsible for mediating the degradation of casein.
Its expression is upregulated in response to injury of the skin suggesting that Epilysin may be involved in tissue repair and homeostasis.
In addition, Epilysin may function predominantly in the nervous system.
Incubation of Epilysin with rat embryonic brain tissue results in the degradation of myelin proteins.
In Xenopus, Epilysin localizes to nerves and is upregulated during neurulation.
This suggests that Epilysin plays an evolutionarily conserved role in neural development and may be involved in modulating the axonal-glial extracellular environment.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human MMP28. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human MMP28.
