The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan.
Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB).
MMP catalysis requires both calcium and zinc.
MMP-21 is 569aa residues in length and consists of a prodomain, catalytic domain, and haemopexin-like domain.
It is the human orthologue for XMMP in X.
laevis and CyMMP in C.
pyrrhogaster.
MMP-21 is expressed in various fetal and adult tissues.
It a possible target gene of the Wnt pathway, and the expression of this protein is controlled by Pax and Notch transcription factors.
MMP-21 may play an important role in embryogenesis, tissue development (particularly in the brain), tumor progression and possibly apoptosis.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human MMP21.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to residues in human MMP21.
