METTL13 is a 699aa protein that exists as multiple alternatively spliced isoforms which are encoded by a gene that maps to human chromosome 1.
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
There are about 3000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.
Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A.
When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs.
The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human METTL13.
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human METTL13.
