Mitogen-activated protein kinase associated protein 1 (MAPKAP-1) is a protein that localizes in the nucleus and is involved in several different signal transduction pathways.
MAPKAP-1 contains one stress-activated map kinase interacting 1 domain (Pfam), a 2nd peroximal domain, and an ER membrane domain (Psort2).
MAPKAP-1 binds to and inhibits c-Jun N-terminal kinase (JNK), and may act as a scaffold molecule in the regulation of JNK signaling.
Transcription of the MAPKAP-1 gene is activated any time the organism is wounded, and stress to the cell causes the MAPKAP-1 protein to be phosphorylated.
Cells lacking this protein may display sterility, multiple stress sensitivity, and a cell-cycle delay.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human MAPKAP1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human MAPKAP1.
