Src is the human homolog of the v-src gene of the Rous sarcoma virus, also known as avian sarcoma virus or ASV.
Src is the first proto-oncogenic non-receptor tyrosine kinase characterized in human.
By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk.
Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion.
Src-family kinases contain an N-terminal cell membrane anchor followed by an SH3 domain and an SH2 domain involved in modular association and activation, respectively.
Src-family kinases are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis.
The human Lyn gene maps to chromosome 8q12 and encodes a 505aa protein.
Hematopoietic tissues predominantly express Lyn, which influences normal immunoglobulin production and regulation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human LYN. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human LYN.
