ChM-1 is a cartilage-specific matrix glycoprotein that stimulates the growth of chondrocytes.
ChM-1 inhibits angiogenesis by disrupting the tube formation of endothelial cells and thus is responsible for the avascular nature of cartilage.
ChM-1 is strongly expressed by the proliferating and hypertrophic zones in the epiphyseal plate of long bones.
ChM-1 accumulates in the interterritorial matrix around the lacunae.
During development, downregulation of ChM-1 permits angiogenesis and ultimately bone formation on the cartilage template.
ChM-1 expression is downregulated in the presence of several growth factors including TGFbeta2, FGF2 and PTHLH.
ChM-1 expression may also play a role in the hypovascularity and chondroid formation of pleomorphic adenomas.
The gene encoding human ChM-1 maps to chromosome 13q14-q21.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human LECT1.
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human LECT1.
