84-4390-89　［取扱停止］LATH (Putative BPIFA4P Protein, BPI fold Containing Family A Member 4 pseudogene, Breast Cancer and Salivary Gland-expressed Protein, Putative Latherin, BPIFA4P, BASE) 50ul　360677

特徴

• The PLUNC family of proteins are encoded by genes which map to chromosome 20 and are thought to play a potential role in the innate immune response in regions of the mouth, nose and lungs.
• As a member of the PLUNC family, BASE (breast cancer and salivary gland-expressed protein) is a 179aa secreted protein that is named for its expression pattern.
• Due to its 63% sequence similarity with the related protein, Latherin, it is suggested that BASE is the major protein in sweat secretions and has important surfactant properties that lower surface tension.
• The expression pattern of BASE in many breast cancer cell lines suggests that it may be an easily accessible diagnostic breast cancer marker.
• Due to the fact that the gene encoding BASE is highly estrogen-repressed, expression of the gene is most likely dependent on HNF-3alpha and estrogen-mediated repression requiring ERalpha.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.