84-4390-77　［取扱停止］KYNU (Kynureninase, L-kynurenine Hydrolase) 50ul　360669

特徴

• Kynureninase, also known as L-kynurenine hydrolase, is a 465aa cytoplasmic enzyme.
• Kynureninase is involved in two pathways; the degredation of L-kynurenine and the biosynthesis of the cofactor NAD(+).
• The main function of kynureninase is to catalyze the cleavage of L-kynurenine into anthranilic acid and of L-3-hydroxykynurenine into 3-hydroxyanthranilic acid, exhibiting a preference for the L-3-hydroxy form.
• Kynureninase forms a homodimer, uses pyridoxal phosphate as a cofactor and is inhibited by o-methoxybenzoylalanine (OMBA).
• Kynureninase is widely expressed, with highest levels found in lung, placenta and liver.
• Deficiency in kynureninase leads to hyperkynureninuria, a disorder characterized by the inability to break down tryptophan to nicotinic acid (vitamin B6).
• Increased levels of kynureninase activity are observed in systemic and cerebral inflammatory conditions.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.