84-4390-41　［取扱停止］KIRREL2 (Kin of IRRE-like Protein 2, Kin of Irregular Chiasm-like Protein 2, Nephrin-like Protein 3, KIRREL2NEPH3, UNQ5827, PRO19646) 50ul　360650

特徴

• NEPH3 (nephrin-like protein 3), also referred to as NLG1, FILTRIN or KIRREL2 (kin of IRRE like 2), is a 708aa protein that is a member of the immunoglobulin superfamily of cell adhesion molecules.
• NEPH3 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues.
• NEPH3 localizes to the interpodocyte filtration slit in the kidney and to the Langerhans islet beta cells in the pancreas.
• NEPH3 is thought to be involved in the maintenance of the glomerular filtration barrier in the kidney and in pancreas development.
• Downregulation of NEPH3 is implicated in several proteinuric diseases.
• Five isoforms exists due to alternative splicing events.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.