84-4389-89　［取扱停止］IRX3 (Iroquois-class Homeodomain Protein IRX-3, Homeodomain Protein IRXB1, Iroquois Homeobox Protein 3, IRX3, IRXB1) 100ul　360619

特徴

• The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system.
• The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice.
• The IRXA group includes IRX, IRX2 and IRX4; the IRXB group comprises IRX3, IRX5 and IRX6.
• IRX1 and IRX2 are both widely expressed during development in the lung epithelium and also in the ventricular septum.
• IRX1 and IRX2 also play a role in digit formation (E11.5–E14.5).
• The IRX gene family members are each expressed in a distinct pattern during mouse heart development.
• Specifically, IRX1 and IRX2 are expressed in the ventricular septum and IRX3 is expressed in the ventricular trabeculated myocardium.
• In addition, IRX4 is expressed in the linear heart tube and the AV canal; IRX5 is expressed in the endocardium lining the ventricular and atrial myocardium.
• Furthermore, the IRX4 gene may modulate cardiac development and function.
• Although the heart of IRX4(-) mice appears to develop normally, adult IRX4(-) mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.