DICE1 (Deleted in Cancer 1) is a protein mapping to chromosome 13q14, which appears to be a tumor suppressor gene in non-small cell lung carcinoma.
Expression of DICE1 is lost or downregulated in most non-small lung carcinomas compared to normal lung tissue.
This is most likely due to a loss of heterozygosity (LOH) of chromosome 13, which is prone to deletions and rearrangements in human lung cancers.
The DICE1 gene is extremely homologous to the mouse protein, DBI-1, at the C-terminal.
DBI-1, when expressed at high levels, interferes with the mitogenic response to IGF-1.
Both DICE1 and DBI-1 contain the highly conserved DEAD-box motif, which suggests that these proteins are involved in critical aspects of cellular function and regulation.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human INTS6. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human INTS6.
