IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFkB and AP-1, thereby promoting host response to injury or infection.
The IL-1 superfamily is comprised of several ligands and receptors.
IL-1F5, also known as IL-1d, IL-1 like protein 1 (IL-1L1), IL-1HY1, IL-1ra (receptor antagonist) homolog 1 or IL-1 related protein 3 (IL-1rp3), is a secreted ligand belonging to this superfamily.
IL-1F5 is expressed in monocytes and macrophages and is activated by endotoxins.
It shares 47% sequence identity with IL-1ra and similarly lacks the loop between the fourth and fifth ∫-strands.
IL-1F5 acts as an antagonist, inhibiting the IL-1F9 activation of NFkB.
Similar to other family members, IL-1F5 can be regulated by bacterial lipopolysaccharide (LPS).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human IL36RN. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to human IL36RN.
