84-4389-28　［取扱停止］IL1R2 (Interleukin-1 Receptor Type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 Antigen-like Family Member B, CDw121b, IL-1 type II Receptor, Interleukin-1 Receptor beta, IL-1R-beta, Interleukin-1 Receptor Type II, CD121b, Interleukin-1 Receptor Type 2, Membrane Form) 50ul　360540

特徴

• Decoy receptors are structurally incapable of activating signaling pathways, but act as anti-inflammatory agents by sequestering agonists for actual signaling complexes.
• The type II IL-1 receptor (IL-1RII) acts as a decoy receptor for the chemokine interleukin-1 (IL-1).
• Additionally, the soluble form of IL-1R accessory protein (IL-1R AcP) increases the affinity of binding of IL-1a and IL-1B to IL-1RII 100-fold, but does not increase the affinity for another antiinflammatory agent, IL-1R antagonist (IL-1Ra).
• The end result is a complex regulatory mechanism for IL-1 activated inflammation, whereby dexamethasone and other molecules inducing IL-1RII, function in an immunosupressive and anti-inflammatory manner.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.