Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-g production and enhances NK cell cytotoxicity.
IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, absent from brain, skeletal muscle, pancreas and kidney.
IL-18R is present in Hodgkin’s disease cell lines, and does not bind IL-1a or IL-1B.
The association of IL-18 to IL-18R leads to activation of NFkB.
At present two subunits of IL-18R have been characterized: IL-18Ra and IL-18RB.
IL-18Ra has been described as the ligand-binding chain and IL-18RB as the signal-transduction chain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human IL8RAP. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human IL8RAP.
