17B-HSD4 (17B-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-BEstradiol 17B-HSD4 (17B-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-B Estradiol dehydrogenase type IV.
It belongs to the 17B-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body.
17B-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol B-oxidation.
It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain.
17B-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6.
17B-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life.
They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human HSD17B4. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human HSD17B4.
