HoxC8 (Homeobox protein Hox-C8, Hox-3A) is a 242aa protein encoded by the human gene HOXC8.
HoxC8 belongs to the Antp homeobox family and contains one homeobox DNA-binding domain.
The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes.
Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis.
Homeobox region 3 contains at least seven homeoboxes within 160kb of DNA.
Overexpression of the HOXC8 transgene causes cartilage defects, the severity of which depends upon transgene dosage.
This abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation.
Since HoxC8 is normally expressed in chondrocytes, it may be responsible for skeletal development other than pattern formation in a tissue-specific manner, hypothetically by controlling the progression of cells along the chondrocyte differentiation pathway.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human HOXC8. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human HOXC8.
