84-4387-95　［取扱停止］HDGFRP3 (HDGF2, Hepatoma-Derived Growth Factor-Related Protein 3, HRP-3, Hepatoma- Derived Growth Factor 2, HDGF-2, CGI-142) 100ul　360394

特徴

• Hepatoma Derived Growth Factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs).
• HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line.
• This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation.
• HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells.
• During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells.
• The HRP (HDGF related proteins) family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4.
• HRP-1 and HRP-4 are only expressed in testis while HRP-2 is widely expressed in different tissues.
• HRP-3 can solely be found in the nervous system.
• Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis, and the cerebellum.
• In the central nervous system, HRP proteins are play a role in neuron proliferation and cell survival.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.