84-4387-72　［取扱停止］HAGH (GLO2, Hydroxyacylglutathione Hydrolase, Mitochondrial, Glyoxalase II, Glx II, HAGH1) 50ul　360381

特徴

• The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP).
• Glyoxalase I and Gyloxalase II (also designated hydroxyacyl glutathione hydrolase or HAGH) are members of the Gyloxalase family.
• The Gyloxalase II enzyme is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form reduced glutathione and D-lactic acid.
• It exists only as a monomer and binds two zinc ions/subunit.
• Glyoxalase II contains 260aa.
• It is detected in the mitochondria and cytosol of mammals.
• Both Glyoxalase I and Gyloxalase II are detected at a higher activity level in breast cancer tissues than with matched unaffected tissues.
• This suggests that glyoxalase inhibitor drugs may be effective in the treatment of cancer.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.